Alzheimer’s Drug Development Revolution: Inflammation and Tau Take Center Stage as Amyloid Era Fades
The 2024 pipeline report reveals a dramatic shift from amyloid to inflammation and tau targets, with repurposed drugs and combination therapies leading a new era of Alzheimer’s treatment. New re...
New research links inflammaging and immunosenescence to Alzheimer’s and Parkinson’s, with immune-modulating therapies showing early promise. Aging of the immune system accelerates brain di...
A recent DGIST study shows somatostatin overexpression reduces inflammation and amyloid β in mice, suggesting repurposing existing drugs like octreotide could accelerate Alzheimer’s therapy and...
Recent research shows probiotics and fecal microbiota transplantation reduce neuroinflammation via the gut-brain axis, offering promising therapies for neurodegenerative diseases with clinical trials ...
Recent research reveals Parabacteroides goldsteinii in the gut contributes to age-related cognitive decline through vagal inflammation, offering potential reversible therapies via microbiome modulatio...
Recent 2023 research shows age-related gut microbiome shifts drive brain inflammation and cognitive decline, with fecal microbiota transplantation and anti-inflammatory diets emerging as promising ant...
A groundbreaking study reveals that depleting the gut microbiome in aged mice improves memory and reduces brain inflammation, highlighting the gut-brain axis as a target for non-invasive aging interve...
Recent research confirms TDP-43 aggregation in vascular dementia, with advancements in biomarkers and therapies highlighting potential for early intervention and personalized prevention. New studies r...
The cGAS-STING pathway, crucial for innate immunity, drives harmful neuroinflammation in aging and Alzheimer’s, with recent studies highlighting therapeutic challenges and biomarker potential fo...
This article explores how senotherapeutics target senescent cells in the brain to reduce neuroinflammation and improve cognition, based on recent preclinical studies and emerging clinical trials. Emer...