A new biomarker derived from the Framingham Heart Study measures the speed of biological decline, offering a more sensitive endpoint for anti-aging clinical trials. A rate-based biomarker from the Fra...
Senomorphic drugs aim to tame the harmful effects of senescent cells without killing them, offering a more targeted approach to age-related diseases. A new wave of drugs called senomorphics could chan...
Senolytic drugs restore stem cell function in aged mice, raising hopes for treating sarcopenia and frailty in humans. But safety hurdles remain. Cellular senescence is stealing stem cells’ regen...
The 2026 Alzheimer’s clinical trials pipeline shows a strategic shift from amyloid to inflammation and tau targets, with combination therapies and repurposed drugs leading the way. In 2026, the Alzh...
Alzheimer’s Drug Development Revolution: Inflammation and Tau Take Center Stage as Amyloid Era Fades
The 2024 pipeline report reveals a dramatic shift from amyloid to inflammation and tau targets, with repurposed drugs and combination therapies leading a new era of Alzheimer’s treatment. New re...
A new study reveals that dasatinib and quercetin (D+Q) cause demyelination in mice, raising safety concerns as over 30 clinical trials test the combo for age-related diseases. A study in Nature Aging ...
Dermatology is shifting from surface-level cosmetics to biology-driven interventions targeting aging hallmarks, with senolytics, epigenetic reprogramming, and biomimetic peptides leading the charge. D...
Phase 1 data for BGE-102 demonstrates significant reductions in hsCRP and inflammatory biomarkers, positioning it as a potential best-in-class therapy for cardiovascular risk and age-related inflammat...
A recent DGIST study shows somatostatin overexpression reduces inflammation and amyloid β in mice, suggesting repurposing existing drugs like octreotide could accelerate Alzheimer’s therapy and...
Phase 1 trial of RLS-1496 demonstrates safety with no severe adverse events and significant reduction in inflammatory markers, highlighting its potential as a senolytic therapy for skin conditions lik...