Research reveals vitamin C’s role in inhibiting ACSL4, reducing iron-driven oxidative damage and senescence in cynomolgus monkeys, positioning it as a promising geroprotective target for human h...
Recent studies show α-eleostearic acid and its methyl ester induce ferroptosis in senescent cells, reducing inflammation and improving muscle function in aged mice without toxicity, with clinical tri...
Senolytic and senomorphic therapies are advancing with compounds like RLS-1496 and α-ESA-me targeting senescent cells. Experts highlight challenges in biomarkers and safety, pushing for personalized ...
Recent breakthroughs in senolytic and senomorphic therapies, including polyunsaturated lipids inducing ferroptosis, are advancing clinical trials for age-related diseases, with a focus on safety and b...
Zhang et al. (2026) discovered that α-eleostearic acid and its methyl ester act as novel senolytic agents by inducing ferroptosis in senescent cells, achieving over 80% clearance with minimal toxicit...
A Nature study shows that the balance of polyunsaturated and monounsaturated fatty acids in diet regulates T cell function through ferroptosis, impacting immunity against infections and cancers, with ...
Recent research reveals ferroptosis, an iron-dependent cell death mechanism, as a key factor in age-related muscle loss, with potential therapies targeting lipid peroxidation. A 2023 study in ‘A...