Recent studies show NLC-encapsulated curcumin and EGCG significantly improve skin retention and SIRT1 expression, offering promising anti-aging benefits.
NLC-encapsulated curcumin and EGCG show enhanced skin retention and anti-aging properties, according to recent studies.
Introduction to NLCs and Their Role in Anti-Aging
Nanostructured lipid carriers (NLCs) have emerged as a revolutionary delivery system in dermatology, particularly for enhancing the bioavailability of bioactive compounds like curcumin and epigallocatechin gallate (EGCG). A 2023 study published in the Journal of Cosmetic Dermatology
demonstrated that NLC-encapsulated curcumin and EGCG showed a 40% increase in skin retention compared to traditional formulations. This breakthrough has significant implications for anti-aging skincare.
Mechanisms of Action: SIRT1 and Collagen Protection
Research published in Antioxidants
(2023) revealed that the combination of curcumin and EGCG significantly upregulated SIRT1 expression by 35%. SIRT1 is a protein known for its role in cellular aging and longevity. Additionally, this combination inhibits collagenase and elastase, enzymes responsible for breaking down collagen and elastin in the skin.
Clinical Trials and Future Applications
Clinical trials in Dermatologic Therapy
(2023) reported a 30% reduction in wrinkles after 12 weeks of using NLC-encapsulated EGCG and curcumin formulations. Researchers at the University of Milan have also patented a novel NLC delivery system for these compounds (Patent WO2023057892, 2023), targeting improved penetration in aged skin.
