A new systems-biology framework explains why lifespan extension becomes harder with organism complexity, urging a shift from single agents to multi-target combination therapies. A new theory says comp...
Researchers combine dichloroacetate and metformin with a 10-fold lower Navitoclax dose, selectively clearing senescent cells while limiting platelet toxicity and advancing clinical senolytic use. A ne...
A 2024 Nature Aging study shows IGF1R inhibitors PPP and NVP-ADW742 extend healthspan by 8–12% but cause GI bleeding and cardiotoxicity, questioning their therapeutic potential. A 2024 mouse study r...
Explore how low-dose stressors like heat, cold, and toxins can activate beneficial stress-response pathways, improving longevity, metabolic health, and cognitive function. Discover the science behind ...